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Newsletters of note

Most of these also make an appearance on my list of blogs. All are recommended, though some of the more prolific ones are best consumed in moderation.


Influence

Similarly to Peter Thiel’s key question in Zero to One, Influence revolves around a list of seven: the seven heuristics our System 1 has accepted as a sign that we can agree to something automatically — what Robert Cialdini calls the Click, run response. Actors both nefarious and benign may use them to get wat they want from us. But of course, it works both ways: we can’t learn defense against the dark arts without picking up some of those dark arts ourselves.

As chance would have it, my finishing the book coincided with a family trip to Las Vegas where all of the principles were tried on us in an attempt to sell us a time share scheme. We got our initial hotel room stays at a well-known and renowned hotel chain (authority) at a discount (reciprocity); the sellers wanted to ingratiate with us with a wink here and a compliment there (liking), citing that she, too, was bilingual and raising a bilingual child (unity); we were taken to a room fool of other potential buyers and witnessed one occasion of a 14,000 point plan being sold (social proof); we had only that day to decide on whether we should buy into this once-in-a-lifetime opportunity (scarcity), and we kept being reminded how much we spent on vacations anyway (commitment and consistency).

They were good, but the book was better: we thanked them for the offer and graciously declined. It was a $15 investment that saved us tens of thousands of dollars in frivolous expenses. Well worth an ocassional re-read.


Don’t Look Up 👎

Netflix has a corrupting influence on film makers. Could it be that good art needs constraints?

Witness Don’t Look Up: a two and a half hour movie in which everything is at stake yet nothing happens. As a government farce, it is worse than Burn After Reading; as a disaster movie, it is worse than even Armageddon; and it is much, much worse than Dr. Strangelove by any criteria.

If it was meant to portray our response to Covid it did a terrible job, painting science as all-knowing and the political-buisness cabal as less coherent than your average B-grade movie villain. Spolier alert: (almost) everyone dies at the end, and you (mostly) won’t care.

Good soundtrack, though.


Goodbye, Drummer (for now)

Drummer is an online outliner that enables quick, easy, and near real-time posting of text both long form and short — what we used to call blogs back in the good old days of two years ago. Dave Winer created it for his own purposes, but it works beautifuly with just your Twitter account as a login. Here is my page.

As things are still very much in progress, Dave recommended doing daily backups. Sadly, I didn’t, and as of today’s updates a few weeks’ worth of half-baked notes are wiped out from the Drummer server (but thankfully not from the website they helped create). That’ll teach me.

Since posting to that page is on hold until everything is back in order, expect more — dare I say daily — updates here. Managing markdown files is not nearly as intutitive or pleasant to use as Dave’s outliner, but he seemes to be working on an OPML to markdown converter. That will be well worth the wait.


Zero to One

Peter Thiel’s thoughts about startups, which I presume every founder past, present, and future has read and internalized.

But I jest. Browse Twitter and you’ll see his seven fairly simple principles of running a successful startup abused, ignored, and misinterpreted, particularly in biotech.

Instead of building a technology that will be useful 20 years from now — the durability factor — technologies are made to solve problems of 20 years ago. Layering optical character recognition, artificial intelligence and machine learning over the cruft of hand-written notes faxed back and forth between doctors’ offices comes to mind. Compare and contrast to mRNA vaccines, a technology created more than a decade ago to treat today’s pandemic.

Instead of developing drugs and other treatments with at least 10 times the effect size of current standards of care — principle of technology — the regulatory agencies and markets are overwhelmed by me-too drugs whose marginal benefit requires mammoth trials for any chance of detection.

Instead of vertical integration and ownership of drug discovery, manufacturing, clinical operations and biomarker development within the same organization, with positive feedback loops between all the factors leading to a faster pace — the team prinicple — we get ghost companies made of slide decks and good wishes whose only tangible impact on the world is achieved via Contract Research Organizations.

I could go on: the principles of timing, monopoly, and distribution are also violated early and often in a biotech startup’s lifetime. But then I’d be breaking a principle myself, that of the secret.


Voices in my head, 2022

Listen to podcasts long enough and you are bound to develop tastes. After 15-some years, mine are these: conversations over stories, with minimal to no editing, and lasting no longer than a couple of hours per episode. Even within these constraints, the list of podcasts I could listen to is near-infinite. Yet these are the few to which I keep returning:

  1. Omnibus, which survived John Roderick’s attempted cancelation to continue providing two poorly-researched topics per week. Highlights of 2021: Mobile Jubilees, The Bottle Conjuror, Officials General, Merkins (yes, those), and The Phantom of New Guinea in which the curious popularity of an obscure Canadian detective show in Serbia makes an appearance.
  2. EconTalk, which continues to be the best general-interest interview show for people who’d rather avoid snake oil salesmen. Highlights of 2021: Dana Giola on poetry (which is in fact the best episode of 2021), Julia Galef on her book Scout Mindset (which I am yet to read, but oh well), Anja Shortland on lost art, Bret Devereaux on ancient Greece and Rome, and Johann Hari on lost connections (which reminded me of a particularly sad episode from my tenure as a heme/onc attending).
  3. Healthcare Unfiltered is the first new healthcare-related podcast I’ve started listening in years. Chadi Nabhan is a good interviewer with an even better access to relevant guests, particularly when he attempts to bring together both sides of a twitter-heated medical debate. Highlights of 2021: Bishal Gyawali on clinical trial design, Aaron Goodman and Matt Wilson on CNS prophylaxis for DLBCL, Barbara Pro and Mehdi Hamadani on PTCL, Mikkael Sekeres and David Steensma on mid-career transition, and Aaron Goodman versus the world, supposedly about randomized clinical trials.
  4. Plenary Session was back on my playlist this year, and mostly Covid-free. Highlights of 2021: Chris Booth, Adam Cifu, Manni Mohyuddin, Bapu Jena, and again Aaron Goodman (who should really start his own podcast instead of squatting in other people’s).
  5. The VPZD Show is the one about Covid. Prasad and Damania have their hearts in the right place and fairly sharp minds; they can evaluate evidence on merits and are willing to admit past mistakes. Without mourning days past when these characteristics were more common — because in fact they weren’t — I’ll just note that in times like these, they are essential. Highlights of 2021 include the entirety of the show, which has only just started.

Previous editions: 2021202020192018The one where I took a break from podcastsThe very first one


Dune (2021) 👍

The 1984 version showed that making a good movie out of a 700-page tome is a complex problem that can’t be solved in 2 hours 17 minutes on a $40M budget. It took 20 minutes and $50M more than that for Denis Villeneuve to cover just half of what Lynch attempted, but the end result is so much better. The story is what it is — between the book, the movie, the TV show, and the game I now know it by heart — but the casting, the pace, cinematography, score, the movieness of it, are all pitch perfect. A cross between Mad Max: Fury Road and Star Wars, noted our perceptive nine-year-old somewhere around the 30-minute mark. Yes, and more like this, please!


Viewing notes: we saw it on a 120” screen with a 5.1 surround system. If you have anything less at home I’d strongly recommend going to a movie theater. Yes, it’s nice that it is available for streaming on day 1, but you would be doing a disservice both to the movie and to yourself seeing it on a postage stamp. \</privilege>


The Mysterious Benedict Society 👍

A Disney+ TV show that WoG followers would like. Villains are IYI vegans who live in modernist buildings and make children live by absurd and contradictory rules that only give an appearance of freedom (“You are free to go wherever you like, as long as you stay on the path”, to paraphrase one). Our heroes, both children and adults, are messy but resourceful, at home in both a Georgian mansion and the wilderness of (I assume, though it’s never specified) the Pacific Northwest.

It starts in a picturesque costal town right off of Townscaper. By the third episodes the children are stuck in a nightmareish brutalist school that is all acute angles and ‘70s orange-white plastic furniture — not nearly as pretty to look at, but the puzzle-of-the-day aspect makes every episode worthwhile. It ends with most of the loose ends tied up but with promises of more to come. And Tony Hale is in almost evey scene. What’s not to love?


A brief chronology of my employment

  • 1994: Fifth grade; I am charged with editing the school newspaper. There is an Intel 386 PC at home that is about to be upgraded to a 486 and do something more than run Lands of Lore.
  • 1996: Seventh grade; I typeset a book of poems1. The school newspaper becomes the school magazine — in layout only; the publishing schedule remains haphazard — as I upgrade from Word 6.0 to QuarkXPress
  • 2000: High school starts again after a freshman year interrupted by NATO bombing. I make the town library’s official website. It is a php hack job laid out in tables instead of the newfangled and to me unknown CSS; it still wins an award.
  • 2002-2008: Med school; I typeset a book here and there and occasionally help out with the library website.
  • 2009: Teaching assistant, Institute for histology and embryology, Belgrade School of Medicine.
  • 2010: Resident, Internal medicine, JHU/Sinai, Baltimore MD.
  • 2013: Chief resident, Internal medicine, as above; I understand the benefits of not being invited to a meeting.
  • 2014: Clinical fellow, hematology/oncology, National Cancer Institute, Bethesda MD.
  • 2016: As above, but also Chief fellow ex tempore for the joint NCI/NHLBI fellowship; my hatred of poorly-run meetings intensifies.
  • 2017: Staff clinician, later to be renamed Assistant research physician, Clinical Trials Team, Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD; the 1994 me marvels at the word salad trailing the title.
  • 2021: Chief Medical Officer, Cartesian Therapeutics.

  1. Someone else’s, to be clear. 


CODA 👍

A few notches below Little Miss Sunshine, a movie of a similar sensibilities. Some changes might have improved it — e.g. why does Ruby end up at high-school choir practice because of a boy, and not because of her love of singing? — but none of it can correct the one huge flaw, which is that conflict between Ruby’s supporting her family by providing free ASL interpreter services and Ruby’s becoming a strong independent young woman is a zero-sum game which will end up in either financial hardship or broken dreams.

But, you know, the music was nice.

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